The Government Medical College, Manjeri, features a robust diagnostic infrastructure centered around its Central Laboratory, which provides 24/7 routine and emergency investigations in Biochemistry, Hematology, and Clinical Pathology. The college is equipped with specialized units for Microbiology (including an accredited RT-PCR lab), Histopathology, and Cytology, handling thousands of monthly samples to support its high-volume 600-bed hospital. Students gain practical experience in these advanced labs, which are complemented by a Radiology Department offering 16-slice CT scans, digital X-rays, high-end ultrasound with color Doppler, and the recently installed MRI scanning unit, ensuring comprehensive clinical training across all diagnostic modalities

The Central Library at Government Medical College, Manjeri, is a specialized information hub covering an area of approximately 1,740 square meters. It maintains a comprehensive collection of over 8,700 medical books and subscribes to 100 national and international journals, ensuring students have access to the latest clinical research and literature

The Government Medical College, Manjeri, situated in Malappuram, features a modern 25-acre campus that seamlessly integrates academic blocks with a high-volume, 600-bed multi-specialty hospital. The infrastructure is centered around a massive five-story academic building housing smart lecture theaters, advanced research laboratories, and a 24/7 central library. Student life is supported by separate, well-equipped multi-story hostels for boys and girls, a dedicated canteen, and sports facilities, all set within a hillside environment. As the first medical college in the district, the campus serves as a major healthcare landmark, offering students a high-density clinical environment and state-of-the-art facilities for medical training.

The Operation Theater (OT) complex at Government Medical College, Manjeri, is a sophisticated surgical hub comprising 12 well-equipped operating suites. These are strategically divided into 8 major theaters for complex surgeries and dedicated minor theaters for smaller procedures and emergency trauma cases. The complex supports a wide range of specialties including General Surgery, Orthopedics, ENT, and OBG, featuring modular designs with advanced instrumentation like operating microscopes, HD camera systems for endoscopies, and modern anesthesia workstations. For students, the hospital integrates clinical learning by providing dedicated viewing areas and a specialized 150-seat hospital lecture theater, allowing for real-time observation and discussion of live surgical cases.

The PCR Lab at Government Medical College, Manjeri, functions as a high-tech molecular diagnostic unit, primarily under the Department of Microbiology. It gained significant prominence as a NABL-accredited RT-PCR hub for COVID-19 testing and has since evolved into a permanent Viral Research and Diagnostic Laboratory (VRDL)